GenXPro is located in the Frankfurt Biotechnology Innovation Center (FIZ) in the Science City Frankfurt am Main, Germany. more
Transcriptomics, Genomics, Epigenomics, Bioinformatics
Nucleotide-based information screening.
By combining intelligent sample preparation with latest next generation- or "deep sequencing" methods, we analyse transcriptomes, genomes and epigenomes at highest resolution.
Our service comprises project planning, consulting, sample preparation, sequencing and bioinformatics.
Thanks to many years of experience with deep sequencing, we have accumulated vast knowledge in low-bias sample preparation of all kinds of different biological samples and provide appropriate solutions for all areas of life science.
Our team of bioinformaticians applies most advanced methods and designs individual solutions to handle the data on our powerful CPU clusters.
Data is delivered in ready-to-use format and includes quality information, quantification, annotation, mapping, Gene Ontology analysis, plots and other graphics.
New papers published:
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 2015 Mar 2
Mazzocca A, Dituri F, De Santis F, Filannino A, Lopane C, Betz RC, Li YY, Mukaida N, Winter P, Tortorella C, Giannelli G, Sabbà C.
Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma.
Cancer Res. 2015 Feb 1;75(3):532-43. doi: 10.1158/0008-5472.CAN-14-1607. Epub 2015 Jan 14.
Zajac BK, Amendt J, Horres R, Verhoff MA, Zehner R.
De novo transcriptome analysis and highly sensitive digital gene expression profiling of Calliphora vicina (Diptera: Calliphoridae) pupae using MACE (Massive Analysis of cDNA Ends).
Forensic Sci Int Genet. 2015 Mar;15:137-46. doi: 10.1016/j.fsigen.2014.11.013.
Reister M, Hoffmeier K, Krezdorn N, Rotter B, Liang C, Rund S, Dandekar T, Sonnenborn U, Oelschlaeger TA.
Complete genome sequence of the gram-negative probiotic Escherichia coli strain Nissle 1917.
J Biotechnol. 2014 Oct 10;187:106-7. doi: 10.1016/j.jbiotec.2014.07.442.
Müller S, Rycak L, Afonso-Grunz F, Winter P, Zawada AM, Damrath E, Scheider J, Schmäh J, Koch I, Kahl G, Rotter B. APADB: a database for alternative polyadenylation and microRNA regulation events Database (Oxford). 2014 Jul 22;2014.
Zawada AM, Rogacev KS, Müller S, Rotter B, Winter P, Fliser D, Heine GH. Massive analysis of cDNA Ends (MACE) and miRNA expression profiling identifies proatherogenic pathways in chronic kidney disease. Epigenetics 2014; 9
New: Please feel free to use our open access miRNA analysis tool "omiRas" (Müller et al. 2013) available at http://tools.genxpro.net/omiras/.
Our unique “TrueQuant” methodology eliminates PCR-introduced bias. We therefore provide truly reliable quantification of transcripts, copy number variations, or methylation-specific tag-counts- even if it was PCR-amplified from minute amounts.
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Keywords of our portfolio are:
RNAseq, deep Seqeuncing, 3’ DGE, SuperSAGE, MACE, PARE, Transcriptomics, De novo Sequencing, Assembly, SNPs, Copy Number Variations (CNVs) , RC-Seq (a variant of RADseq), Reduced Representation Libraries, Normalisation of cDNA and DNA, CpG Islands, Methylation, Digital Karyotyping, Exome Sequening, Target enrichment, qPCR, ChiP Seq and barcoded Sequencing, Bioinformatics, SMART Breeding