Transcriptomics, Genomics, Epigenomics
Nucleotide-based information screening.
By combining intelligent sample preparation with latest next generation sequencing methods, we analyse transcriptomes, genomes and epigenomes at highest resolution.
Data is delivered in ready-to-use format and includes quality information, quantification, annotation, mapping, Gene Ontology analysis, plots and other graphics.
Our unique “TrueQuant” methodology eliminates PCR-introduced bias. We therefore provide truly reliable quantiftcation of transcripts, copy number variations, or methylation-specific tag-counts- even if it was PCR-amplified from minute amounts.
Our team of bioinformaticians applies most advanced methods and designs individual solutions to handle the data on our powerful CPU clusters.
Keywords of our portfolio are:
RNAseq, 3’ DGE, SuperSAGE, MACE, PARE, Transcriptomics, De novo Sequencing, Assembly, SNPs, Copy Number Variations (CNVs) , RADseq, Reduced Representation Libraries, Normalisation of cDNA and DNA, CpG Islands, Methylation, Digital Karyotyping, Exome Sequening, Target enrichment, qPCR, ChiP Seq and barcoded Sequencing.
New Techniques:
-Massive Analysis of cDNA Ends (MACE) click for .ppt or brochure
-Whole Exome Sequencing
Sample shipping: Please download form here.
New Papers Out:
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.
Zawada AM, Rogacev KS, Rotter B, Winter P, Marell RR, Fliser D, Heine GH. Blood. 2011 Jul 29 [Epub ahead of print]
Short read Illumina data for the de novo assembly of a non-model snail species transcriptome (Radix balthica, Basommatophora, Pulmonata), and a comparison of assembler performance. Feldmeyer B, Wheat CW, Krezdorn N, Rotter B, Pfenninger M.; BMC Genomics 2011, 12:317
Physiological and molecular analysis of polyethylene glycol-induced reduction of aluminium accumulation in the root tips of common bean (Phaseolus vulgaris).Yang ZB, Eticha D, Rotter B, Rao IM, Horst WJ.New Phytol. 2011 Jun 13. doi: 10.1111/j.1469-8137.2011.03784.x.
"The salt-responsive transcriptome of chickpea roots and nodules via deepSuperSAGE" ; Molina C. Zaman-Allah M, Khan F., Fatnassi N, Horres R, Rotter B. Steinhauer D. Amenc L, Drevon JJ, Winter P, and Kahl G ; BMC Plant Biology 2011, 11:31doi:10.1186/1471-2229-11-31
Apomictic and sexual ovules of Boechera display heterochronic global gene expression patterns.
Sharbel et al. Plant Cell. 2010 Mar;22(3):655-71. Epub 2010 Mar 19.
SuperSAGE analysis of the Nicotiana attenuata transcriptome after fatty acid-amino acid elicitation (FAC): identification of early mediators of insect responses.Gilardoni et al. BMC Plant Biol. 2010 Apr 14;10:66.
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