Transcriptomics, Genomics, Epigenomics, Bioinformatics
Nucleotide-based information screening.
By combining intelligent sample preparation with latest next generation- or "deep sequencing" methods, we analyse transcriptomes, genomes and epigenomes at highest resolution.
Our service comprises project planning, consulting, sample preparation, sequencing and bioinformatics.
Thanks to many years of experience with deep sequencing, we have accumulated vast knowledge in low-bias sample preparation of all kinds of different biological samples and provide appropriate solutions for all areas of life science.
Our team of bioinformaticians applies most advanced methods and designs individual solutions to handle the data on our powerful CPU clusters.
Data is delivered in ready-to-use format and includes quality information, quantification, annotation, mapping, Gene Ontology analysis, plots and other graphics.
New papers published:
Müller S, Rycak L, Afonso-Grunz F, Winter P, Zawada AM, Damrath E, Scheider J, Schmäh J, Koch I, Kahl G, Rotter B. APADB: a database for alternative polyadenylation and microRNA regulation events Database (Oxford). 2014 Jul 22;2014.
Zawada AM, Rogacev KS, Müller S, Rotter B, Winter P, Fliser D, Heine GH. Massive analysis of cDNA Ends (MACE) and miRNA expression profiling identifies proatherogenic pathways in chronic kidney disease. Epigenetics 2014; 9
New: Please feel free to use our open access miRNA analysis tool "omiRas" (Müller et al. 2013) available at http://tools.genxpro.net/omiras/.
Our unique “TrueQuant” methodology eliminates PCR-introduced bias. We therefore provide truly reliable quantification of transcripts, copy number variations, or methylation-specific tag-counts- even if it was PCR-amplified from minute amounts.
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Keywords of our portfolio are:
RNAseq, deep Seqeuncing, 3’ DGE, SuperSAGE, MACE, PARE, Transcriptomics, De novo Sequencing, Assembly, SNPs, Copy Number Variations (CNVs) , RC-Seq (a variant of RADseq), Reduced Representation Libraries, Normalisation of cDNA and DNA, CpG Islands, Methylation, Digital Karyotyping, Exome Sequening, Target enrichment, qPCR, ChiP Seq and barcoded Sequencing, Bioinformatics, SMART Breeding